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Artículo original 05 de noviembre de 2023

Relación de los signos clínicos motores en personas con sospecha de enfermedad de Parkinson y la captación de 99mTc-TRODAT-1 en imágenes gammagráficas cerebrales con SPECT

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Abstract

Objective: To establish the relationship between clinical motor signs and Technetium-99m Tropane (99mTc-TRODAT-1) uptake in the basal ganglia, in scintigraphy images with Single Photon Emission Computed Tomography (SPECT) acquisition, in people with suspected Parkinson disease, that attended the Nuclear Medicine Service of Hospital México, during the years 2017 and 2018.

Methods: The study sample of this research were people with suspected Parkinson disease that have 99mTc-TRODAT-1 images with SPECT acquisition, attended at the Nuclear Medicine Department of the Hospital México during the years 2017 and 2018. Using specialized software tools and an anatomical template, a spatial normalization process and quantitative analysis were applied to each image to obtain the average values of counts per pixel (cpp) in the basal ganglia. With the values obtained, the Specific Uptake Ratio (SUR) value was calculated for the anatomical structures of interest and subsequently a series of statistical tests and data analysis were executed.

Results: According to the values obtained for the three anatomical structures of interest (caudate nucleus, globus pallidus and putamen), considering the clinical motor signs, the anatomical structure values of SUR with differences close to significance between the clinical motor sign is the caudate nucleus for the tremor (p = 0,0675). According to the laterality of the anatomical structures of interest, the only significant value was the one that corresponds to the average cpp values for the caudate nucleus (p < 0,001).

Conclusion: According to the results, the people who presented tremor tended to present higher values of SUR and greater uptake at the level of the caudate nucleus. In addition, it was possible to demonstrate the existence of a significant difference between the average cpp values registered at the level of the right caudate nucleus and the average cpp values registered at the level of the left caudate nucleus of the study sample, presenting higher values in the left one.

Key words: Parkinson’s disease, S{PECT, basal ganglia, radiopharmaceuticals, nuclear medicine.